RESEARCH: DIABETES
FOLDING PROJECT #14927 PROFILE

This project looks at how certain proteins on our cells change shape when they receive signals. These proteins are involved in things like diabetes and blood pressure. By understanding how they work, scientists can design better drugs to treat these diseases.

Note: This TLDR is a simplication and may not be 100% accurate.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

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G-Protein Coupled Receptors

G-protein coupled receptors (GPCRs)

G-Protein Coupled Receptors are a large family of cell surface proteins that play a vital role in transmitting signals from outside the cell to inside. They are involved in various physiological processes, including hormone signaling, neurotransmission, and immune responses. Dysregulation of GPCRs is implicated in many diseases, making them attractive drug targets.

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GPCRs

G-Protein Coupled Receptors

A short form of G-Protein Coupled Receptors. These are a large family of cell surface proteins crucial for transmitting signals within the body.

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Glucagon Receptor

A receptor protein that binds to the hormone glucagon.

The Glucagon Receptor is a protein found on the surface of cells. It's responsible for receiving the hormone glucagon, which helps regulate blood sugar levels.

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Glucagon-like Peptide 1 receptor

A receptor protein that binds to the hormone glucagon-like peptide 1.

The Glucagon-like Peptide 1 Receptor is a protein found on cells and responds to the hormone GLP-1. It helps regulate blood sugar levels and promotes satiety.

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PArathyroid Hormone Receptor

A receptor protein that binds to the hormone parathyroid hormone.

The Parathyroid Hormone Receptor is a protein found on cells. It responds to the hormone PTH, which regulates calcium levels in the body.

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Pituitary Adenylate Cyclase-Activating Polypeptide

A peptide hormone that activates adenylate cyclase in the pituitary gland.

This is a hormone that influences the release of other hormones from the pituitary gland. It plays a role in various bodily functions.

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Secretin Receptor

A receptor protein that binds to the hormone secretin.

The Secretin Receptor is a protein found on cells in the digestive system. It responds to the hormone secretin, which helps regulate the secretion of pancreatic enzymes.