RESEARCH: DIABETES
FOLDING PROJECT #14924 PROFILE

This project relates to studying how certain proteins on cells change shape. These proteins are involved in diseases like diabetes and high blood pressure. By understanding how they work, scientists hope to create better medications that target these proteins.

G-Protein Coupled Receptors: G-Protein coupled receptors (GPCRs) are membrane proteins involved in the pathogenesis of diabetes, high blood pressure, osteoporosis, etc.

Here, we are trying to study the conformational dynamics of the Glucagon Receptor, Glucagon-like Peptide 1 receptor, PArathyroid Hormone Receptor, Pituitary Adenlyate Cyclase Receptor and Secretin Receptor - All Class B GPCRs.

These studies will help in designing better drugs that target these receptors.

G-Protein Coupled Receptors

G protein-coupled receptors (GPCRs)

G Protein Coupled Receptors (GPCRs) are a large family of cell surface proteins that play a crucial role in transmitting signals from the outside to the inside of cells. They are involved in various physiological processes, including hormone signaling, neurotransmission, and sensory perception. Many drugs target GPCRs because they are implicated in numerous diseases.

Glucagon Receptor

A receptor protein that binds to the hormone glucagon.

The Glucagon Receptor is a protein found on the surface of cells in the liver. When it binds to the hormone glucagon, it triggers a series of events that lead to the release of glucose into the bloodstream. This helps regulate blood sugar levels.

Glucagon-like Peptide 1 receptor

GLP-1 Receptor

The Glucagon-like Peptide 1 receptor (GLP-1R) is a protein found on the surface of cells in various organs, including the pancreas. When it binds to the hormone GLP-1, it stimulates insulin release and suppresses glucagon secretion, helping regulate blood sugar levels.

Parathyroid Hormone Receptor

A receptor protein that binds to the hormone parathyroid hormone.

The Parathyroid Hormone Receptor is a protein found on the surface of bone cells and other tissues. When it binds to parathyroid hormone, it stimulates calcium release from bones and promotes calcium reabsorption in the kidneys.

Pituitary Adenylate Cyclase-Activating Polypeptide Receptor

PACAP Receptor

The Pituitary Adenylate Cyclase-Activating Polypeptide receptor (PAC1R) is a protein found on the surface of various cells. When it binds to PACAP, it activates signaling pathways involved in regulating hormone release, neurotransmission, and other physiological processes.

Secretin Receptor

A receptor protein that binds to the hormone secretin.

The Secretin Receptor is a protein found on the surface of cells in the pancreas and other gastrointestinal tissues. When it binds to the hormone secretin, it stimulates bicarbonate secretion from the pancreas, helping neutralize stomach acid in the small intestine.