RESEARCH: COVID-19
FOLDING PROJECT #14852 PROFILE

Folding@home is using your computer to simulate COVID-19 proteins and learn how they work. This helps researchers find potential drug targets for the virus. You can help by joining their projects online.

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

Coronavirus

A type of virus that causes respiratory illness.

Coronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The most recent coronavirus, SARS-CoV-2, causes the disease COVID-19.

COVID-19

Coronavirus disease 2019

COVID-19 is a contagious respiratory illness caused by the SARS-CoV-2 virus. It can cause mild to severe symptoms, including fever, cough, shortness of breath, and loss of taste or smell. Severe cases can lead to pneumonia, respiratory failure, and death.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus that causes COVID-19. It is a type of coronavirus that was first identified in Wuhan, China, in December 2019.

Proteins

Large biomolecules essential for all biological processes.

Proteins are the workhorses of our cells, carrying out a vast array of functions. They build and repair tissues, transport molecules, fight infections, and catalyze chemical reactions. Proteins are made up of chains of amino acids, which fold into complex 3-dimensional structures.

Drug Targets

Molecules or cellular processes that can be inhibited by drugs to treat diseases.

Drug targets are specific molecules or pathways within the body that play a role in disease development. By inhibiting these targets, drugs can aim to alleviate symptoms and slow or stop the progression of the disease.

Main Protease

An enzyme essential for viral replication.

The main protease is a key enzyme produced by viruses, including coronaviruses. It plays a crucial role in cleaving viral proteins, which are necessary for the virus to assemble new infectious particles and replicate.