RESEARCH: COVID-19
FOLDING PROJECT #14814 PROFILE

Folding@home is using computers to study proteins from the COVID-19 virus. This helps researchers understand how the virus works and find potential drug targets. You can help by joining their project! More info: https://foldingathome.org/news/

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

CORONAVIRUS

A contagious respiratory illness caused by the SARS-CoV-2 virus.

Coronavirus is a family of viruses that can cause illnesses ranging from the common cold to more severe diseases like COVID-19. The disease is spread through respiratory droplets released when an infected person coughs, sneezes, or talks. Symptoms can include fever, cough, shortness of breath, and fatigue. Vaccines and antiviral medications are available to help prevent and treat coronavirus infection.

COVID-19

Coronavirus disease 2019

COVID-19 is the infectious disease caused by the SARS-CoV-2 virus. It primarily affects the respiratory system and can lead to severe illness, including pneumonia, acute respiratory distress syndrome (ARDS), and death. Symptoms can range from mild to life-threatening and may include fever, cough, shortness of breath, fatigue, loss of taste or smell, and more.

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It is a type of coronavirus that spreads primarily through respiratory droplets released when an infected person coughs, sneezes, or talks. The virus can infect the cells lining the respiratory tract, leading to the symptoms of COVID-19.

Protein

A large biomolecule consisting of one or more chains of amino acids.

Proteins are essential molecules found in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes. Proteins are made up of building blocks called amino acids, which are linked together in specific sequences to form polypeptide chains.

Inhibitor

A substance that decreases the activity of a biological process or molecule.

Inhibitors are molecules that block or reduce the activity of enzymes or other proteins. They play crucial roles in drug development, as many medications work by inhibiting specific targets involved in disease processes. Inhibitors can be natural compounds, synthetic drugs, or genetic modifications.

Main Protease

A viral enzyme essential for the replication of certain viruses, including SARS-CoV-2.

The main protease is a crucial enzyme that coronaviruses use to replicate. It cleaves viral proteins, enabling the virus to assemble new copies of itself within infected cells. Inhibiting this enzyme can prevent viral replication and is a key target for antiviral drugs against COVID-19.

Folding

The process by which a protein assumes its characteristic three-dimensional shape.

Folding is essential for proteins to function properly. The specific sequence of amino acids in a protein determines its unique three-dimensional structure. This folded shape allows proteins to interact with other molecules and perform their specific roles in cells.