RESEARCH: COVID-19
FOLDING PROJECT #14827 PROFILE

Folding@home is using computers to simulate proteins from the coronavirus to learn how they work. This info can help scientists find drugs to fight COVID-19. The project has multiple parts focused on different parts of the virus. Check https://foldingathome.org for updates.

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

Coronavirus

A type of virus that causes respiratory illnesses.

Coronaviruses are a large family of viruses that can cause diseases in animals and humans. Some coronaviruses, like SARS-CoV-2 (which causes COVID-19), can be very dangerous to people.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus that causes COVID-19. It's a type of coronavirus that was first identified in Wuhan, China, in late 2019.

COVID-19

Coronavirus Disease 2019

COVID-19 is the infectious disease caused by the SARS-CoV-2 virus. It can cause a wide range of symptoms, from mild to severe.

Main Protease

A crucial enzyme in the replication cycle of coronaviruses.

The main protease is a protein that plays a vital role in how coronaviruses replicate. By inhibiting this enzyme, scientists hope to develop antiviral drugs to treat COVID-19.

Receptor Binding Domains

Regions on the surface of coronaviruses that bind to host cells.

Receptor binding domains are parts of the coronavirus spike protein that allow the virus to attach to and enter human cells. Understanding these domains is crucial for developing treatments and vaccines.

Drug Targets

Molecules or cellular processes that can be inhibited to treat a disease.

Drug targets are specific molecules or pathways within the body that are involved in causing a disease. By developing drugs that target these areas, scientists aim to prevent or treat the illness.

Inhibitor

A substance that reduces the activity of another molecule, such as an enzyme.

Inhibitors are molecules that block or slow down the action of other molecules. They are often used in drug development to target specific proteins involved in disease processes.