RESEARCH: COVID-19
FOLDING PROJECT #14833 PROFILE

Folding@home is using computer power to study proteins from the COVID-19 virus. These projects aim to understand how these proteins work and identify potential drug targets. You can contribute by running simulations on your computer.

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

Coronavirus

A type of virus that causes respiratory illness.

Coronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like SARS and MERS. The most recent coronavirus outbreak is caused by SARS-CoV-2 and has resulted in the global pandemic known as COVID-19.

COVID-19

Coronavirus Disease 2019

COVID-19 is the infectious disease caused by the SARS-CoV-2 virus. It primarily affects the respiratory system and can range in severity from mild symptoms to severe pneumonia and death. The global pandemic caused by COVID-19 has significantly impacted public health and economies worldwide.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It is a type of coronavirus that emerged in late 2019 and rapidly spread globally. The virus primarily infects respiratory cells and can lead to various symptoms, including fever, cough, shortness of breath, and loss of taste or smell.

Main Protease

An enzyme crucial for viral replication.

The main protease is a vital enzyme found in coronaviruses, including SARS-CoV-2. It plays a critical role in the virus's life cycle by cleaving viral proteins into smaller functional units needed for replication and assembly of new viruses. Many antiviral drugs target this enzyme to inhibit viral replication.

Inhibitor

A substance that blocks or slows down a biological process.

An inhibitor is a molecule that binds to another molecule and reduces its activity. In pharmacology, inhibitors are often used as drugs to target specific enzymes or proteins involved in disease processes. For example, protease inhibitors block the action of proteases like the main protease in coronaviruses.

Folding@home

A distributed computing project that uses volunteer computer resources to simulate protein folding.

Folding@home is a citizen science project that harnesses the power of millions of computers worldwide to simulate how proteins fold. Proteins are essential biomolecules that perform diverse functions in living organisms, and their ability to fold into specific shapes is crucial for their function. Folding@home contributes to scientific research by providing valuable insights into protein folding dynamics and aiding in the development of new drugs and therapies.