RESEARCH: COVID-19
FOLDING PROJECT #14810 PROFILE

Folding@home is using CPU power to simulate coronavirus proteins. This helps researchers understand how these proteins work and find potential drug targets. The project focuses on the main protease, a key enzyme in the virus's life cycle. For more info, visit https://foldingathome.org/news/

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

Coronavirus

A type of virus that causes respiratory illness.

Coronaviruses are a large family of viruses that can cause illnesses in humans and animals. Symptoms include fever, cough, shortness of breath, and fatigue. Some coronaviruses can be deadly.

COVID-19

Coronavirus Disease 2019

COVID-19 is the infectious disease caused by the SARS-CoV-2 virus. It was first identified in Wuhan, China, in December 2019 and quickly spread worldwide, causing a global pandemic. Symptoms can range from mild to severe, including fever, cough, shortness of breath, and loss of taste or smell.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It belongs to a family of viruses known as coronaviruses and can infect humans through respiratory droplets.

Main protease

An enzyme essential for the replication of viruses.

Main protease is a crucial enzyme found in coronaviruses like SARS-CoV-2. It plays a vital role in viral replication by cleaving viral proteins, allowing them to assemble and spread. Inhibiting this enzyme is a potential strategy for developing antiviral drugs against COVID-19.

Potential drug targets

Molecules or biological processes that can be inhibited by drugs to treat diseases.

Potential drug targets are specific molecules or pathways within a disease-causing organism or pathway that scientists believe can be blocked by drugs to treat the disease. In the context of COVID-19, researchers are identifying potential drug targets in the virus itself, such as the main protease.