RESEARCH: COVID-19
FOLDING PROJECT #14811 PROFILE

This project uses computer power to simulate how proteins from the COVID-19 virus work. Understanding these proteins could help scientists develop new drugs to fight the virus. You can join by running special projects on your computer.

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

CORONAVIRUS

A group of viruses that cause respiratory illnesses.

Coronaviruses are a large family of viruses that can cause diseases ranging from the common cold to more severe illnesses like SARS and MERS. The virus responsible for the COVID-19 pandemic is called SARS-CoV-2.

COVID-19

Coronavirus disease 2019

COVID-19 is the infectious disease caused by the SARS-CoV-2 virus. Symptoms can range from mild to severe and may include fever, cough, shortness of breath, fatigue, and loss of taste or smell. The disease can lead to serious complications such as pneumonia, acute respiratory distress syndrome (ARDS), and death.

SARS-CoV-2

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It is a type of coronavirus that spreads primarily through respiratory droplets released when an infected person coughs, sneezes, or talks.

Main protease

An enzyme essential for the replication of SARS-CoV-2.

The main protease is a key protein involved in the life cycle of the SARS-CoV-2 virus. It plays a crucial role in cleaving viral proteins, which are necessary for the virus to replicate and spread. Inhibiting this enzyme is a potential therapeutic strategy for treating COVID-19.

Drug targets

Molecules or proteins that can be inhibited by drugs to treat diseases.

Drug targets are specific molecules within the body that play a role in disease processes. By inhibiting these targets with drugs, it is possible to disrupt the pathways involved in disease and alleviate symptoms. Identifying potential drug targets is a crucial step in developing new treatments.

Inhibitor

A substance that binds to a target molecule and reduces its activity.

Inhibitors are molecules that can block the function of other molecules, such as enzymes or receptors. They are often used in medicine to treat diseases by interfering with the action of harmful proteins.