RESEARCH: COVID-19
FOLDING PROJECT #14813 PROFILE

Folding@home is using CPU power to simulate proteins from the coronavirus. This helps researchers understand how these proteins work and find potential drug targets. These projects supplement existing GPU projects focused on other parts of the virus. For the latest updates, check Folding@home's website.

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

Coronavirus

A type of virus that causes respiratory illness.

Coronaviruses are a large family of viruses that can cause illnesses in animals and humans. Some coronaviruses, like the one responsible for COVID-19, can be highly contagious and spread easily from person to person. Symptoms of coronavirus infection can range from mild to severe and may include fever, cough, shortness of breath, and fatigue.

COVID-19

Coronavirus Disease 2019

COVID-19 is a respiratory illness caused by the SARS-CoV-2 virus. It emerged in late 2019 and quickly spread worldwide, leading to a global pandemic. Symptoms can range from mild to severe, and some people may experience long-term health effects (long COVID).

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus that causes COVID-19. It belongs to a family of viruses known as coronaviruses and can spread through respiratory droplets released when an infected person coughs, sneezes, or talks.

Main protease

An enzyme essential for the replication of SARS-CoV-2.

The main protease is a key protein that coronaviruses use to replicate. It plays a crucial role in cutting viral proteins, which are necessary for the virus to assemble new copies of itself. Researchers are developing drugs that target this enzyme to inhibit viral replication and treat COVID-19.

Inhibitor

A substance that blocks the activity of another molecule.

An inhibitor is a molecule that binds to a target protein and prevents it from functioning properly. In drug discovery, inhibitors are often designed to block the activity of specific enzymes or proteins involved in disease processes.

Drug targets

Molecules or proteins that can be targeted by drugs to treat diseases.

Drug targets are specific molecules or proteins that play a role in disease development. By targeting these molecules with drugs, researchers aim to disrupt the disease process and improve patient outcomes.