RESEARCH: COVID-19
FOLDING PROJECT #14822 PROFILE

Folding@home is using computers to simulate how proteins in the coronavirus work. This helps researchers find potential drugs. These projects focus on the main protease, a key part of the virus. Check https://foldingathome.org for updates.

CORONAVIRUS PROJECT These projects are part of Folding@home’s efforts to assist researchers around the world taking up the global fight against COVID-19.

At the time of release, this is the latest news update: https://foldingathome.org/2020/03/10/covid19-update/ These projects are CPU projects to simulate COVID-19 proteins to learn about their dynamics and function.

These supplement high-priority GPU projects of the main protease as well as the COVID-19 receptor binding domains.

All can be considered potential drug targets. Please stay tuned to https://foldingathome.org/news/ for more current updates. ALL of these projects are Coronavirus SARS-CoV-2 main protease in complex with a potential inhibitor: series project number ------- ------- 72_RL 14800
387_RL 14801
387_RL 14802
387_RL 14803
387_RL 14804
387_RL 14805
387_RL 14806
387_RL 14807
387_RL 14808
AGG_RL 14809
AGG_RL 14810
AGG_RL 14811
AGG_RL 14812
AGG_RL 14813
AGG_RL 14814
AGG_RL 14815
AGG_RL 14816
BRO_RL 14717
BRO_RL 14718
BRO_RL 14719
BRO_RL 14820
MLTN_RL 14821
MS0323_RL 14822
MS0326_RL 14823
MS0326_RL 14824
MS0331_RL 14825
MS0406_RL 14852
MS0406-2_RL 14854
GUZ_RL 14858.

Coronavirus

A type of virus that causes respiratory illness.

Coronaviruses are a large family of viruses that can cause illnesses ranging from the common cold to more severe diseases like Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The most recently emerged coronavirus, SARS-CoV-2, is responsible for the disease COVID-19.

COVID-19

Coronavirus Disease 2019

COVID-19 is an infectious disease caused by the SARS-CoV-2 virus. Symptoms can range from mild (fever, cough, fatigue) to severe (pneumonia, respiratory failure). It spreads primarily through respiratory droplets released when an infected person coughs or sneezes.

SARS-CoV-2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus that causes COVID-19. It belongs to a family of viruses called coronaviruses, which can cause respiratory illnesses in humans and animals.

Drug Targets

Molecules or biological pathways that can be targeted by drugs to treat diseases.

Drug targets are specific molecules or processes within the body that are involved in disease development. By identifying and targeting these drug targets, researchers can develop medications that interfere with the disease process.

Main Protease

An enzyme essential for viral replication.

The main protease is a crucial enzyme found in many viruses, including SARS-CoV-2. It plays a vital role in viral replication by cleaving viral proteins into smaller functional units.

Receptor Binding Domains

Regions on viral proteins that bind to host cell receptors.

Receptor binding domains are specific regions on viral proteins that allow the virus to attach and enter host cells. Understanding these binding sites is crucial for developing antiviral therapies.

Inhibitor

A substance that blocks or reduces the activity of a specific molecule or enzyme.

Inhibitors are often used in drug development to target specific enzymes or proteins involved in disease processes. By inhibiting their activity, drugs can help alleviate or treat symptoms.