RESEARCH: CANCER
FOLDING PROJECT #12921 PROFILE

Proteins are like origami, they fold into specific shapes. Sometimes mistakes in the instructions (mutations) make them fold wrong, causing diseases like cancer and Alzheimer's. This project looks at how different protein mutations change their folding speed to help us understand and predict these problems.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biological molecules essential for many bodily functions.

Proteins are complex molecules that perform a wide variety of functions in living organisms. They are involved in processes such as transporting oxygen, catalyzing reactions, and providing structural support. Understanding protein structure and function is crucial for understanding how cells work.

Misfolding

Failure of a protein to fold into its correct 3-dimensional shape.

Proteins have complex 3D shapes that are essential for their function. When a protein misfolds, it can lose its ability to perform its job correctly. Misfolded proteins can accumulate in cells and contribute to diseases such as Alzheimer's and Parkinson's.

Mutation

A change in the DNA sequence.

Mutations are alterations in the genetic code. They can be caused by errors during DNA replication or exposure to mutagens such as radiation. Mutations can have a wide range of effects, from being harmless to causing disease.

Cancer

A group of diseases involving abnormal cell growth.

Cancer is a complex group of diseases characterized by uncontrolled cell division. Cancer cells can invade surrounding tissues and spread to other parts of the body.

Alzheimer's

A progressive neurodegenerative disease.

Alzheimer's disease is a progressive brain disorder that leads to memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia.