RESEARCH: CANCER
FOLDING PROJECT #12916 PROFILE

Proteins are like tiny machines that need to fold into the right shape to work. Sometimes, changes in their code (mutations) can mess up this folding process, leading to diseases like cancer and Alzheimer's. This project studies how these mutations affect protein folding to help us understand and maybe even prevent these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biomolecule composed of amino acids.

Proteins are essential molecules found in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

Peptide

Short chain of amino acids linked together.

Peptides are short chains of amino acids, the building blocks of proteins. They play important roles in various biological processes, such as signaling, hormone regulation, and immune responses.

Mutation

Permanent change in the DNA sequence.

Mutations are alterations in the genetic code (DNA). They can occur spontaneously or be induced by environmental factors. Mutations can have various effects, ranging from being harmless to causing disease.

Conformation

3D shape of a molecule.

Conformation refers to the three-dimensional arrangement of atoms within a molecule. The shape of a molecule is crucial for its function.

Cancer

Disease characterized by uncontrolled cell growth.

Cancer is a group of diseases involving abnormal cell growth and spread. It can affect various organs and tissues in the body.

Alzheimer's

Progressive neurodegenerative disease.

Alzheimer's disease is a brain disorder that causes memory loss, thinking problems, and behavioral changes. It is the most common form of dementia.