RESEARCH: CANCER
FOLDING PROJECT #12908 PROFILE

Proteins are like tiny machines that fold into specific shapes to work properly. Sometimes, changes in their code (mutations) can mess up this folding, causing diseases like cancer and Alzheimer's. This project aims to study how these mutations affect protein folding to better understand and predict these problems.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biomolecules essential for various biological functions.

Proteins are complex molecules that play crucial roles in all living organisms. They are involved in a wide range of processes, including building and repairing tissues, transporting molecules, catalyzing reactions, and providing structural support.

Misfolding

Failure of a protein to adopt its correct three-dimensional structure.

Protein misfolding occurs when a protein cannot fold into its proper shape. This can lead to dysfunction and disease because the protein can no longer perform its intended role.

Mutation

A permanent alteration in the DNA sequence.

Mutations are changes in the genetic code that can affect protein function. They can be inherited or acquired during an organism's lifetime and can range from small changes to large-scale alterations.

Cancer

A group of diseases characterized by uncontrolled cell growth.

Cancer is a complex group of diseases involving abnormal cell growth and spread. It can affect any part of the body and is often caused by genetic mutations.

Alzheimer's

A neurodegenerative disease characterized by memory loss and cognitive decline.

Alzheimer's disease is a progressive brain disorder that affects memory, thinking, and behavior. It is the most common cause of dementia and is characterized by the buildup of abnormal protein deposits in the brain.