RESEARCH: CANCER
FOLDING PROJECT #12917 PROFILE

Protein misfolding happens when a protein can't fold properly. Changes in the protein's code can cause this, leading to diseases like cancer and Alzheimer's. The project relates to studying how these changes affect how proteins fold so we can better understand and predict these problems.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biomolecule essential for various biological functions.

Proteins are complex molecules found in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes. Protein misfolding, where a protein fails to adopt its correct 3-dimensional shape, can lead to various diseases.

Misfolding

The process where a protein fails to adopt its correct 3-dimensional structure.

Misfolding occurs when a protein doesn't fold properly into its intended shape. This can disrupt the protein's function and lead to various health problems. Understanding misfolding is crucial for developing treatments for diseases like Alzheimer's and Parkinson's.

Mutations

Permanent alterations in the DNA sequence.

Mutations are changes in the genetic code. They can occur spontaneously or be induced by environmental factors. Mutations can have a wide range of effects, from being harmless to causing disease.

Cancer

A disease characterized by uncontrolled cell growth.

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. Mutations in genes that regulate cell growth can contribute to cancer development.

Alzheimer's

A progressive neurodegenerative disease.

Alzheimer's disease is a brain disorder that gradually destroys memory and thinking skills. Protein misfolding and accumulation are implicated in the development of Alzheimer's.