RESEARCH: CANCER
FOLDING PROJECT #12915 PROFILE

Proteins are like tiny machines that need to fold into specific shapes to work properly. Sometimes, changes in the protein's instructions (DNA) can cause it to misfold, leading to diseases like cancer and Alzheimer's. This project looks at how different mutations affect how proteins fold, hoping to understand and predict these problems better.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biological molecules essential for life.

Proteins are complex molecules that perform many vital functions in living organisms. They are involved in processes such as building and repairing tissues, transporting molecules, catalyzing chemical reactions, and defending against disease.

Misfolding

When a protein fails to fold into its correct three-dimensional shape.

Misfolding occurs when proteins don't adopt their intended shapes. This can disrupt their function and lead to diseases like Alzheimer's and Parkinson's.

Mutation

A change in the DNA sequence.

Mutations are alterations in the genetic code. They can be inherited or occur spontaneously and can sometimes lead to changes in protein structure and function.

Alzheimer's

A progressive neurodegenerative disease.

Alzheimer's disease is a brain disorder that causes memory loss, thinking problems, and behavioral changes. It is characterized by the buildup of abnormal protein deposits in the brain.

Cancer

Uncontrolled cell growth.

Cancer is a group of diseases characterized by abnormal cell growth and spread. It can affect various organs and tissues in the body.