RESEARCH: CANCER
FOLDING PROJECT #12910 PROFILE

Proteins need to fold correctly to work. Sometimes mutations mess up this folding, causing diseases like cancer and Alzheimer's. This project studies how different mutations affect protein folding so we can better understand and treat these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

A large molecule consisting of chains of amino acids.

Proteins are essential biomolecules that perform a vast array of functions in living organisms. They are composed of amino acid building blocks and fold into specific three-dimensional structures to carry out their roles.

Misfolding

The failure of a protein to fold into its correct three-dimensional shape.

Misfolding occurs when proteins do not achieve their proper shape due to alterations in their amino acid sequence or environmental factors. This can lead to dysfunction and various diseases.

Mutation

A permanent change in the DNA sequence of an organism.

Mutations are alterations in the genetic code that can lead to variations in traits. While some mutations are harmless, others can cause diseases or affect protein function.

Alzheimer's

A progressive neurodegenerative disease characterized by memory loss and cognitive decline.

Alzheimer's disease is a brain disorder that gradually destroys memory and thinking skills. It is the most common cause of dementia.

Cancer

A group of diseases characterized by uncontrolled cell growth and spread.

Cancer is a broad term for diseases that arise from abnormal cell division. It can affect various organs and tissues in the body.