RESEARCH: CANCER
FOLDING PROJECT #12909 PROFILE

Proteins need to fold into specific shapes to work properly. Sometimes, changes in the protein's code (mutations) mess up this folding, leading to diseases like cancer and Alzheimer's. The project relates to studying how these mutations affect how proteins fold so we can better understand and prevent these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

A large biomolecule composed of amino acids linked in a chain.

Proteins are essential molecules found in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, providing structural support, transporting molecules, and regulating cellular processes.

Misfolding

The process by which a protein fails to attain its correct three-dimensional structure.

Protein misfolding occurs when a protein cannot fold into its proper shape. This can disrupt the protein's function and lead to diseases.

Mutations

Changes in the DNA sequence of a gene.

Mutations are alterations in the genetic code. They can be inherited or acquired during an organism's lifetime and can have various effects on protein function.

Conformation

The three-dimensional shape of a molecule.

Conformation refers to the arrangement of atoms in a molecule. Proteins can have different conformations depending on their environment and function.

Cancer

A disease characterized by uncontrolled cell growth.

Cancer is a group of diseases involving abnormal cell growth and spread. It can affect various organs and tissues in the body.

Alzheimer's

A neurodegenerative disease characterized by memory loss and cognitive decline.

Alzheimer's disease is a progressive brain disorder that affects memory, thinking, and behavior. It is the most common cause of dementia.