RESEARCH: CANCER
FOLDING PROJECT #12919 PROFILE

Proteins are like tiny machines that need to fold correctly to work. Sometimes, changes in their building blocks (DNA) mess up this folding, causing diseases like cancer and Alzheimer's. This project looks at how these errors affect protein folding speed to help us understand and maybe even prevent these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

A large biomolecule composed of chains of amino acids.

Proteins are essential macromolecules that perform diverse functions in living organisms. They are involved in processes such as catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

Misfolding

The inability of a protein to fold into its correct three-dimensional structure.

Protein misfolding occurs when a protein fails to adopt its proper shape. This can lead to dysfunctional proteins that aggregate and contribute to various diseases.

Mutation

A permanent alteration in the DNA sequence.

Mutations are changes in the genetic code that can affect protein structure and function. They can be inherited or arise spontaneously during cell division.

Cancer

A group of diseases characterized by uncontrolled cell growth.

Cancer is a complex group of diseases involving abnormal cell proliferation and spread. It can affect various organs and tissues.

Alzheimer's

Alzheimer's disease (AD)

Alzheimer's disease is a progressive neurodegenerative disorder characterized by memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia.