RESEARCH: CANCER
FOLDING PROJECT #12918 PROFILE

Proteins are made up of chains that fold into specific shapes. Sometimes, changes in the protein's code (mutations) can mess up this folding process, leading to diseases like cancer and Alzheimer's. The project relates to studying how these mutations affect protein folding so we can better understand and treat these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biomolecules essential for various biological functions.

Proteins are complex molecules that play vital roles in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

Misfolding

Incorrect folding of a protein into its native conformation.

Misfolding occurs when a protein fails to fold into its correct three-dimensional shape. This can lead to dysfunctional proteins that aggregate and cause cellular damage, contributing to diseases like Alzheimer's.

Mutations

Changes in the DNA sequence that can alter protein structure and function.

Mutations are alterations in the genetic code. They can introduce changes in amino acid sequences, leading to altered protein properties and potentially contributing to diseases.

Alzheimer's

A progressive neurodegenerative disease characterized by memory loss and cognitive decline.

Alzheimer's disease is a debilitating brain disorder that causes gradual memory loss, thinking difficulties, and behavioral changes. It is associated with the accumulation of abnormal protein deposits in the brain.

Cancer

Uncontrolled growth and spread of abnormal cells.

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It can affect various organs and tissues in the body.