RESEARCH: CANCER
FOLDING PROJECT #12912 PROFILE

Proteins need to fold correctly to work. Sometimes mutations change how they fold, leading to diseases like cancer and Alzheimer's. This project studies how different mutations affect protein folding to better understand these diseases.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

Protein

Large biomolecules essential for various biological functions.

Proteins are complex molecules that perform many vital roles in living organisms. They are involved in processes like building and repairing tissues, transporting molecules, and catalyzing chemical reactions. Misfolding of proteins can lead to diseases like Alzheimer's and cancer.

Peptide

A short chain of amino acids linked together.

Peptides are chains of amino acids, the building blocks of proteins. They often have specific functions and can act as signaling molecules or hormones. Proteins are made up of one or more peptides.

Mutation

A permanent change in the DNA sequence.

Mutations are changes in the genetic code. They can be caused by various factors and may have no effect, beneficial effects, or harmful effects. Mutations can lead to variations in traits and contribute to diseases like cancer.

Conformation

The three-dimensional shape of a molecule.

Conformation refers to the specific arrangement of atoms within a molecule. The shape of a protein is crucial for its function. Changes in conformation can alter a protein's ability to interact with other molecules.

Cancer

A disease characterized by uncontrolled cell growth.

Cancer is a group of diseases involving abnormal cell growth. Cancer cells divide uncontrollably and can invade surrounding tissues. Treatment options include surgery, chemotherapy, and radiation therapy.

Alzheimer's

A neurodegenerative disease causing memory loss and cognitive decline.

Alzheimer's disease is a progressive brain disorder that affects memory, thinking, and behavior. It is the most common cause of dementia, characterized by the buildup of amyloid plaques and tau tangles in the brain.