RESEARCH: CANCER
FOLDING PROJECT #12911 PROFILE

Proteins sometimes fold incorrectly due to changes in their code (mutations). This can cause diseases like cancer and Alzheimer's. The project relates to figuring out how these mutations affect protein folding so we can better understand and treat these diseases.

Note: This TLDR is a simplication and may not be 100% accurate.

Protein misfolding occurs when a peptide cannot fold into its native structure.

Mutations in the protein sequence may cause alterations of the native folded conformation, leading to diseases such as cancer and Alzheimer's.

Understanding protein misfolding as a function of mutations is currently one of the biggest challenges in the biological sciences.

We aim to systematically study folding rates of diverse mutated proteins to better understand and predict folding dynamics.

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Protein

A large biomolecule composed of amino acids linked together in a chain.

Proteins are essential macromolecules found in all living organisms. They perform a vast array of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

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Peptide

A short chain of amino acids linked together by peptide bonds.

Peptides are small chains of amino acids. They are important building blocks for proteins and play various roles in biological systems, such as signaling, immunity, and enzymatic activity.

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Mutations

Permanent changes in the DNA sequence.

Mutations are alterations in the genetic code that can have a range of effects on an organism. Some mutations are harmless, while others can cause diseases or alter traits.

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Conformation

The three-dimensional shape of a molecule.

Conformation refers to the specific spatial arrangement of atoms within a molecule. It is crucial for biological function as the shape of a molecule determines its interactions with other molecules.

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Diseases

Conditions that impair normal bodily function.

Diseases are medical conditions characterized by abnormal symptoms, signs, and physiological changes. They can result from various factors, including genetic predispositions, infections, environmental exposures, and lifestyle choices.

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Cancer

A group of diseases characterized by uncontrolled cell growth and spread.

Cancer is a serious disease that arises from the abnormal growth and proliferation of cells. It can affect various organs and tissues in the body.

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Alzheimer's

A progressive neurodegenerative disease.

Alzheimer's disease is a debilitating brain disorder that causes memory loss, cognitive decline, and behavioral changes. It is the most common cause of dementia.

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Folding

The process by which a protein assumes its functional three-dimensional shape.

Protein folding is a complex process where a polypeptide chain coils and folds into a specific shape. This shape is essential for the protein to perform its biological function.

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Mutations

Permanent changes in the DNA sequence.

Mutations are alterations in the genetic code that can have a range of effects on an organism. Some mutations are harmless, while others can cause diseases or alter traits.