RESEARCH: CANCER
FOLDING PROJECT #17790 PROFILE

This project looks at how proteins use ion power to move molecules across cell membranes. These proteins are important for many processes in the body and are even targets for some medicines! By studying them, we can learn how they work across different types of organisms.

Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Molecular basis

The fundamental mechanisms underlying molecular structure and function.

Molecular basis refers to the intricate ways molecules interact and behave. In biochemistry, it's crucial for understanding how proteins like transporters work.

Secondary active transporters

Proteins that use an ion gradient to drive the transport of other molecules across cell membranes.

Secondary active transporters are crucial for moving molecules across cell walls. They utilize the energy from an existing ion gradient to transport various substances, like nutrients or drugs.

Ion gradient

The difference in concentration of ions across a cell membrane.

An ion gradient is like an electrical potential created by having different amounts of charged particles (ions) on either side of a membrane. This difference drives many biological processes, including transport.

Drug targets

Molecules or pathways that are involved in disease processes and can be inhibited or modulated by drugs.

Drug targets are specific molecules or cellular processes that contribute to a disease. By targeting these, drugs can effectively treat or manage the condition.

Simulations

Computer models used to mimic biological processes or systems.

Simulations are powerful tools that allow scientists to study complex biological systems without needing to conduct experiments in the real world. They can help predict how molecules interact and how drugs might work.