RESEARCH: CANCER
FOLDING PROJECT #17767 PROFILE

This project looks at how proteins called secondary active transporters use ions to move molecules across cell membranes. These transporters are important for many processes in our bodies and are being studied as potential drug targets for diseases like cancer and diabetes.

Note: This TLDR is a simplication and may not be 100% accurate.

Projects 17745-17750 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

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Secondary active transporters

Proteins that use ions to transport molecules across cell membranes.

Secondary active transporters are crucial proteins found in all living organisms. They help move various molecules across cell membranes by using the energy stored in ion gradients. This process is vital for many cellular functions and plays a significant role in treating diseases like cancer, diabetes, and neurological disorders.

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Ion Gradient

A difference in ion concentration across a cell membrane.

An ion gradient is a difference in the concentration of electrically charged atoms (ions) across a cell membrane. This concentration difference creates potential energy that can be used by cells to power various processes, including the transport of molecules across membranes.

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Simulations

Computer models used to study complex systems.

Simulations are computer programs that mimic the behavior of real-world systems. In research, simulations are widely used to study complex biological processes, predict outcomes, and test hypotheses without conducting physical experiments.

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Proteins

Large biomolecules essential for all living organisms.

Proteins are complex molecules that play vital roles in all living organisms. They perform a wide range of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

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Drug Targets

Molecules or pathways that are involved in disease processes and can be targeted by drugs.

Drug targets are specific molecules or cellular pathways involved in the development and progression of diseases. By targeting these molecules with drugs, researchers aim to inhibit or modulate their function and ultimately treat the disease.

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Cancer

A group of diseases characterized by uncontrolled cell growth.

Cancer is a group of diseases characterized by the abnormal and uncontrolled growth of cells. This uncontrolled growth can spread to other parts of the body, damaging tissues and organs.

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Diabetes

A group of metabolic disorders characterized by high blood sugar levels.

Diabetes is a group of metabolic disorders that affect how the body regulates blood sugar (glucose). In diabetes, either the body doesn't produce enough insulin, or it can't effectively use the insulin it produces. This leads to high blood sugar levels, which can damage various organs and tissues.

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Neurological Disorders

A range of disorders that affect the brain, spinal cord, or nerves.

Neurological disorders encompass a wide range of conditions that affect the brain, spinal cord, and nerves. These disorders can cause a variety of symptoms, such as weakness, numbness, pain, seizures, and cognitive impairment.