RESEARCH: CANCER
FOLDING PROJECT #17776 PROFILE

This project studies how proteins use ions to move molecules across cell membranes. These 'secondary active transporters' are found everywhere and help with important processes. They're also drug targets for diseases like cancer and diabetes. By simulating these proteins, we can learn how they work the same way despite different structures.

Projects 17745-17750 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Transporters

Proteins that move molecules across cell membranes.

Transporters are essential proteins found in all living organisms. They facilitate the movement of various substances, including nutrients, ions, and waste products, across cell membranes. This process is crucial for maintaining cellular homeostasis and carrying out vital biological functions.

Secondary Active Transporters

Transporters that use an ion gradient to move molecules across cell membranes.

Secondary active transporters are a type of membrane protein that utilize the electrochemical gradient created by ions to drive the transport of other molecules. This process is crucial for various cellular functions, such as nutrient uptake, waste removal, and signal transduction.

Ion Gradient

A difference in ion concentration across a membrane.

An ion gradient refers to the unequal distribution of ions across a cell membrane. This difference in concentration creates an electrochemical potential that drives various cellular processes, including the movement of nutrients and waste products.

Simulations

Computer models used to study complex systems.

Simulations are powerful tools used in various scientific disciplines to model and analyze complex systems. In computational biology, simulations can be employed to study biological processes, such as protein folding or drug interactions.

Proteins

Large biomolecules essential for life.

Proteins are complex macromolecules that play a vital role in virtually all biological processes. They are responsible for a wide range of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.