RESEARCH: CANCER
FOLDING PROJECT #17775 PROFILE

This project looks at how proteins called secondary active transporters move molecules across cell membranes using ions. These transporters are important for many bodily functions and are targets for drugs to treat diseases like cancer and diabetes. By studying them, we can learn more about how different types of proteins work together.

Projects 17745-17750 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Secondary active transporters

Proteins that use ion gradients to transport molecules across cell membranes.

Secondary active transporters are essential proteins found in all living organisms. They utilize an existing ion gradient to power the movement of various molecules across cell membranes. This mechanism is crucial for many cellular processes, including nutrient uptake and waste removal. These transporters are also important drug targets for treating diseases like cancer, diabetes, and neurological disorders.

Ion Gradient

Difference in ion concentration across a membrane.

An ion gradient is the difference in concentration of charged particles (ions) between two areas, often separated by a membrane. This concentration difference creates potential energy that can be harnessed to drive various cellular processes, such as the movement of molecules across membranes.

Membrane Transporters

Proteins that facilitate the movement of molecules across cell membranes.

Membrane transporters are essential proteins embedded in cell membranes that regulate the passage of molecules into and out of cells. They play a vital role in maintaining cellular homeostasis, nutrient uptake, waste removal, and signaling.

Drug Targets

Molecules or proteins that are therapeutic targets for drug development.

Drug targets are specific molecules or cellular processes that are implicated in the development or progression of diseases. By inhibiting or modulating these targets, drugs can effectively treat various medical conditions.

Simulations

Computer models used to mimic biological systems or processes.

Simulations are powerful tools used in computational biology to study complex biological systems. They involve creating computer models that mimic the behavior of molecules, cells, or entire organisms. Simulations can be used to explore various biological phenomena, predict drug interactions, and design new therapeutic strategies.