RESEARCH: CANCER
FOLDING PROJECT #17787 PROFILE

Secondary active transporters are proteins that use ion gradients to move molecules across cell membranes. These transporters are found in all living things and are important for many bodily functions. The project relates to understanding how these transporters work, which could lead to new drugs for diseases like cancer and diabetes.

Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Secondary active transporters

Proteins that use ion gradients to transport molecules across cell membranes.

Secondary active transporters are crucial proteins found in all living organisms. They work by using the energy from an existing ion gradient to move other molecules, like nutrients or drugs, across cell membranes. This process is vital for many biological functions and is often targeted by medications for diseases like cancer and diabetes.

Ion gradient

A difference in concentration of ions across a membrane.

An ion gradient refers to the unequal distribution of charged particles (ions) on either side of a cell membrane. This difference in concentration creates electrical potential energy that can be used by cells to power various processes, such as transporting molecules across the membrane.

Simulations

Computer-based models used to mimic biological processes.

Simulations are powerful tools used in bioinformatics and other scientific fields to study complex systems. By creating computer models of biological processes, researchers can explore different scenarios, test hypotheses, and gain insights into how things work at a molecular level.

Proteins

Large biomolecules essential for cell structure and function.

Proteins are the workhorses of cells, carrying out a vast array of functions. From building tissues to catalyzing biochemical reactions, proteins are essential for life as we know it.