RESEARCH: CANCER
FOLDING PROJECT #17766 PROFILE

The project relates to understanding how proteins use ion power to move molecules across cell membranes. These proteins are found everywhere in life and are even drug targets for diseases like cancer and diabetes. By studying them, we can learn how different types of proteins work together.

Projects 17745-17750 Molecular basis of secondary active transporters. Secondary active membrane transporters are proteins that utilize ions to transport an assortment of molecules across cell membranes.

These proteins are found in all domains in life and surprisingly, despite vastly different structures, operate under the same mechanism by using an ion gradient to assist in small molecule transport.

Furthermore, many of these secondary active transporters are drug targets to treat diseases like cancer, diabetes, and neurological disorders.

The simulations in this project will allow us to understand a universal role of ion-coupling across different families of proteins.

Secondary active transporters

Proteins that use ions to transport molecules across cell membranes.

Secondary active transporters are crucial proteins found in all living organisms. They utilize the energy stored in an ion gradient to move various molecules across cell membranes. These transporters play vital roles in numerous biological processes and are often targeted by drugs for treating diseases like cancer, diabetes, and neurological disorders.

Membrane transporters

Proteins embedded in cell membranes that facilitate the movement of molecules across the membrane.

Membrane transporters are proteins embedded within cell membranes. They act as gatekeepers, selectively allowing specific molecules to enter or exit the cell. These transporters play essential roles in various cellular processes, including nutrient uptake, waste removal, and signal transduction.

Ion gradient

A difference in concentration of ions across a membrane.

An ion gradient refers to an unequal distribution of charged atoms (ions) across a cell membrane. This difference in concentration creates an electrochemical potential that drives various cellular processes, including the function of secondary active transporters.

Proteins

Large, complex molecules essential for the structure and function of all living organisms.

Proteins are the workhorses of the cell. They perform a vast array of functions, including catalyzing biochemical reactions, transporting molecules, providing structural support, and regulating cellular processes.

Simulations

Computer models used to mimic and study real-world processes.

Simulations are powerful tools used in biotechnology to model complex biological systems. By running computer simulations, researchers can investigate various scenarios, test hypotheses, and gain insights into biological mechanisms.