RESEARCH: COVID-19
FOLDING PROJECT #17419 PROFILE

This project studies the SARS-CoV-2 virus's main copying tool (nsp12). Scientists want to find weaknesses in this tool by looking for gaps where drugs could fit and see how changes to the tool affect how well drugs work.

Note: This TLDR is a simplication and may not be 100% accurate.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

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SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for the COVID-19 pandemic. It's a respiratory virus that causes severe illness in some people.

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nsp12

Non-structural protein 12

NSP12 is a viral protein essential for SARS-CoV-2 replication. It acts as the RNA polymerase, copying the virus's genetic material.

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polymerase

An enzyme that catalyzes the synthesis of polymers from monomers

Polymerases are crucial enzymes that build long chains of molecules like DNA and RNA. In the case of SARS-CoV-2, the polymerase copies the virus's genetic material.

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druggable pockets

Regions on a protein's surface that can bind to drug molecules

Druggable pockets are specific sites on proteins that scientists aim to target with drugs. Finding these pockets helps develop new medications.

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mutations

Permanent alterations in the DNA sequence of an organism

Mutations are changes in the genetic code. In viruses like SARS-CoV-2, mutations can lead to new variants and affect drug effectiveness.

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drug sensitivity

The extent to which a pathogen or cell is affected by a drug

Drug sensitivity refers to how susceptible a virus or organism is to the effects of a particular drug. Mutations can alter this sensitivity.