RESEARCH: COVID-19
FOLDING PROJECT #17405 PROFILE

This project studies the SARS-CoV-2 virus's main copying tool (nsp12). Scientists want to find weak spots on this tool that drugs can target and see how changes in the tool affect drug effectiveness.

Note: This TLDR is a simplication and may not be 100% accurate.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

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SARS-Cov2

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 is the virus that causes COVID-19. It's a type of coronavirus that spreads easily from person to person through respiratory droplets. Symptoms can range from mild to severe and may include fever, cough, shortness of breath, fatigue, and loss of taste or smell.

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nsp12

Non-structural protein 12

NSP12 is a key protein produced by SARS-CoV-2. It acts as an RNA polymerase, which means it's responsible for copying the virus's genetic material (RNA). This process is essential for viral replication and spreading.

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Polymerase

An enzyme that catalyzes the formation of a polymer from monomers.

Polymerases are essential enzymes involved in building long chains of molecules like DNA and RNA. They play crucial roles in processes like DNA replication, transcription (making RNA from DNA), and translation (making proteins from RNA).

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Genome

The complete set of genetic information in an organism.

A genome is the entire collection of DNA within an organism. It contains all the instructions needed to build and maintain that organism. The genome can be thought of as a blueprint for life.

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Drug Sensitivity

A measure of how responsive a cell or organism is to the effects of a drug.

Drug sensitivity refers to how much of a specific drug is needed to produce a desired effect. Some cells or organisms are more sensitive than others, meaning they respond to lower doses of medication.

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Mutations

Permanent alterations in the DNA sequence.

Mutations are changes that occur in an organism's DNA sequence. They can be caused by various factors like radiation or errors during DNA replication. Mutations can have a range of effects, from being harmless to causing disease.