RESEARCH: COVID-19
FOLDING PROJECT #17402 PROFILE

This project studies the SARS-Cov2 virus's copying machine (nsp12). Scientists want to find places on this machine where drugs could fit and block it, and also see how changes in the machine affect drug effectiveness.

Note: This TLDR is a simplication and may not be 100% accurate.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

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SARS-Cov2

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It is a type of coronavirus that primarily affects the respiratory system.

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nsp12

Non-structural protein 12

NSP12 is a viral protein found in SARS-CoV-2. It plays a crucial role in replicating the virus's genetic material (RNA).

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Polymerase

An enzyme that catalyzes the synthesis of nucleic acids.

Polymerase is a type of enzyme that helps build DNA and RNA molecules. In viruses like SARS-CoV-2, polymerase replicates their genetic material.

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RNA-directed RNA polymerase

An enzyme that synthesizes RNA from an RNA template.

RNA-directed RNA polymerase is a specialized type of polymerase found in some viruses. It uses existing RNA to create new RNA copies, which are essential for viral replication.

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Genome

The complete set of genetic material in an organism.

A genome is like the instruction manual for a living thing. It contains all the genes that determine an organism's traits and characteristics.

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Mutations

Permanent changes in the DNA sequence.

Mutations are alterations in the genetic code. They can be caused by various factors and can lead to changes in an organism's traits.

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Drug sensitivity

The ability of a microorganism or cell to respond to a drug.

Drug sensitivity refers to how well an organism responds to a particular medication. It's important for determining effective treatment strategies.

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Pockets

Small cavities or depressions on the surface of a molecule.

Pockets are often found on proteins and can serve as binding sites for other molecules, such as drugs.