RESEARCH: COVID-19
FOLDING PROJECT #17401 PROFILE

This project studies the SARS-CoV-2 virus's main copying tool (nsp12). By creating simulations, scientists hope to find weaknesses in this tool that can be targeted by drugs. They also want to see how changes in the tool affect how well drugs work.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for the disease COVID-19. It's a type of coronavirus that can cause respiratory illness in humans.

nsp12

Non-structural protein 12

NSP12 is a key enzyme within the SARS-CoV-2 virus. It's responsible for replicating the virus's genetic material (RNA), allowing it to spread and infect new cells.

Polymerase

An enzyme that catalyzes the synthesis of nucleic acids.

Polymerases are essential for life as they build DNA and RNA molecules. In viruses like SARS-CoV-2, they are vital for replicating the virus's genetic code.

RNA

Ribonucleic acid

RNA is a type of genetic material that carries instructions for building proteins. It's different from DNA in its structure and function.