RESEARCH: COVID-19
FOLDING PROJECT #17417 PROFILE

This project looks at the virus part that makes copies of itself. Scientists want to find places on this part where drugs could attach and stop the virus, and see how changes in the virus affect how well drugs work.

Note: This TLDR is a simplication and may not be 100% accurate.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

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SARS-Cov2

Severe acute respiratory syndrome coronavirus 2

SARS-CoV-2 is the virus that causes COVID-19. It's a type of coronavirus that spreads through respiratory droplets and can lead to severe respiratory illness.

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nsp12

Non-structural protein 12

NSP12 is a viral protein essential for replicating the SARS-CoV-2 genome. It acts as an RNA-dependent RNA polymerase, copying the virus's genetic material.

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polymerase

An enzyme that catalyzes the formation of polymers (like DNA or RNA) from monomers.

Polymerases are crucial enzymes that build long chains of molecules like DNA and RNA. They play a vital role in processes like gene expression and replication.

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druggable pockets

Regions on a protein's surface that can be targeted by drugs.

Druggable pockets are specific sites on proteins where drugs can bind and exert their effects. Scientists aim to identify these pockets for developing new therapies.

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mutations

Permanent alterations in the DNA sequence.

Mutations are changes in the genetic code. They can be harmless or lead to disease by altering protein function.

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drug sensitivity

A cell's or organism's susceptibility to the effects of a drug.

Drug sensitivity refers to how effectively a drug works on a particular target. Understanding this helps in tailoring treatments for individual patients.