RESEARCH: COVID-19
FOLDING PROJECT #17400 PROFILE

This project looks at the SARS-Cov2 virus's ability to copy its genetic material. Researchers will try to find places on the virus protein that drugs could target and see how changes in the virus affect drug effectiveness.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is a virus that causes COVID-19. It's a type of coronavirus that spreads through respiratory droplets from an infected person.

nsp12

Non-structural protein 12

NSP12 is a viral protein crucial for replication. It's found in SARS-CoV-2 and acts as an RNA polymerase, copying the virus's genetic material.

Polymerase

An enzyme that synthesizes DNA or RNA from a template.

Polymerases are essential for copying genetic material. In viruses like SARS-CoV-2, the polymerase helps create more copies of its own genome.

Drug

A substance used to treat or prevent disease.

Drugs are chemical compounds designed to interact with biological systems and have a specific therapeutic effect. The goal is to develop drugs that target diseases effectively.

Mutation

A permanent alteration in the DNA sequence.

Mutations are changes in the genetic code. They can arise spontaneously or be induced by environmental factors. Mutations can have various effects, including altering protein function and contributing to disease.