RESEARCH: COVID-19
FOLDING PROJECT #17416 PROFILE

This project uses computer simulations to study the SARS-CoV-2 virus's main copying tool (nsp12). Researchers want to find weaknesses in this tool that could be targeted by new drugs. They also want to see how changes (mutations) in the tool might affect how well drugs work.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV-2 is the virus responsible for causing COVID-19. It's a type of coronavirus that infects the respiratory system and can cause a range of symptoms from mild to severe.

nsp12

Non-structural protein 12

NSP12 is a key enzyme within the SARS-CoV-2 virus. It's called RNA-directed RNA polymerase because it makes copies of the virus's RNA genetic material.

Polymerase

An enzyme that catalyzes the synthesis of DNA or RNA.

Polymerases are essential proteins that build chains of DNA or RNA. They play a crucial role in copying genetic information and making new molecules.

Drug

A substance used for the treatment, prevention, or diagnosis of a disease.

Drugs are chemical substances designed to have a specific effect on the body. They can be used to treat illnesses, prevent infections, and manage symptoms.

Mutation

A permanent alteration in the DNA sequence.

Mutations are changes in the genetic code that can affect how an organism functions. They can be caused by errors during DNA replication or exposure to mutagens.