RESEARCH: COVID-19
FOLDING PROJECT #17418 PROFILE

This project studies the SARS-CoV-2 virus's key protein that makes copies of its genetic material. Scientists will use computer models to find areas on this protein where drugs could attach and block its activity. They'll also see how changes in the protein's code affect drug effectiveness.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

SARS-CoV2

Severe Acute Respiratory Syndrome Coronavirus 2

SARS-CoV2 is a virus that causes COVID-19. It's a type of coronavirus known for its ability to spread quickly and cause severe respiratory illness.

nsp12

Non-structural protein 12

NSP12 is a key protein in the SARS-CoV2 virus. It's an RNA polymerase, which means it helps the virus copy its genetic material.

Polymerase

An enzyme that synthesizes polymers from monomers.

Polymerases are biological machines that build long chains of molecules. In the case of RNA polymerase, it builds RNA chains using DNA as a template.

Drug Sensitivity

The degree to which a cell or organism responds to a drug.

Drug sensitivity describes how well a particular substance works against a target. A sensitive organism is easily affected by a drug, while a resistant one requires a higher dose for the same effect.

Mutations

Permanent alterations in the DNA sequence.

Mutations are changes in the genetic code. They can be small changes in a single letter or large-scale rearrangements of DNA. Mutations are the driving force behind evolution and can lead to new traits.