RESEARCH: COVID-19
FOLDING PROJECT #17404 PROFILE

This project studies the SARS-Cov2 virus's ability to copy its own genetic code. Scientists will use computer simulations to find weak spots on the virus protein that drugs could target, and see how changes in the virus affect drug effectiveness.

Note: This TLDR is a simplication and may not be 100% accurate.

This project simulates the SARS-Cov2 nsp12 polymerase (RNA-directed RNA polymerase), which is responsible for duplicating the SARS-Cov2 genome during infection.

These simulations will focus on identifying druggable pockets on the protein's surface as well as predicting the effect of mutations on drug sensitivity.

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SARS-Cov2

Severe Acute Respiratory Syndrome Coronavirus 2.

SARS-CoV-2 is the virus responsible for causing COVID-19. It's a type of coronavirus that spreads through respiratory droplets and can cause severe respiratory illness.

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nsp12

Non-structural protein 12

NSP12 is a viral protein found in coronaviruses like SARS-CoV-2. It's the enzyme responsible for copying the virus's genetic material (RNA) during infection.

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polymerase

An enzyme that catalyzes the synthesis of polymers from monomers.

Polymerases are essential enzymes that build long chains of molecules like DNA and RNA. They play a crucial role in processes like DNA replication and gene expression.

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RNA-directed RNA polymerase

An enzyme that uses RNA as a template to synthesize new RNA molecules.

RNA-directed RNA polymerases are enzymes found in some viruses, including coronaviruses. They copy the virus's RNA genome during infection.

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mutations

Changes in the DNA sequence of an organism.

Mutations are alterations in the genetic code. They can be caused by various factors and can lead to changes in an organism's traits.

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drug sensitivity

The ability of a cell or organism to respond to the effects of a drug.

Drug sensitivity describes how responsive a particular cell, tissue, or organism is to a specific medication. Understanding this helps determine appropriate dosages and treatment strategies.