RESEARCH: PARKINSONS
FOLDING PROJECT #17915 PROFILE

This project uses computer simulations to study the serotonin transporter, a protein that affects mood and behavior. By looking at how changes in the transporter's structure affect its function, researchers hope to better understand mental disorders like depression and Parkinson's disease, and develop new treatments.

Note: This TLDR is a simplication and may not be 100% accurate.

These projects contains simulations of the serotonin transporter, the protein responsible for terminating neurotransmission in neurons.

The neurotransmitter serotonin regulates various functions in the body such as mood, behavior, appettite, and sleep, and is a major drug targets for antidepressants.

Malfunctions in the serotonin transporter have been assoicated with mental disorders including depression and Parkinson's.

Our goal in performing these simulations is to understand how mutations affect the structure and dynamics of the serotonin transporter and provide insights to treat psychatric disorders assoicated with these mutations.

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serotonin transporter

A protein that removes serotonin from the synapse.

The serotonin transporter is a crucial protein in the brain. It moves serotonin out of the spaces between neurons (synapses), effectively stopping its action and regulating mood, behavior, appetite, and sleep. Disruptions in this transporter can contribute to mental health conditions like depression and Parkinson's disease.

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neurotransmission

The process of transmitting signals between neurons.

Neurotransmission is how our brain communicates. It involves the release of chemical messengers called neurotransmitters from one neuron (sender) across a tiny gap (synapse) to another neuron (receiver). This allows for complex information processing and control of bodily functions.

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serotonin

A neurotransmitter that regulates mood, sleep, appetite, and other functions.

Serotonin is a chemical messenger in the brain. It plays a vital role in regulating mood, happiness, sleep, appetite, and even digestion. Low levels of serotonin are linked to depression and anxiety, while medications like antidepressants often work by increasing serotonin activity.

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antidepressants

Medications that treat depression and other mood disorders.

Antidepressants are a class of drugs used to treat depression, anxiety, and other mental health conditions. They work by affecting the balance of certain chemicals in the brain, such as serotonin, norepinephrine, and dopamine. Common types include selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants.

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Parkinson's

A neurodegenerative disorder that affects movement.

Parkinson's disease is a progressive brain disorder that causes tremors, stiffness, slow movements, and balance problems. It's caused by the loss of dopamine-producing cells in a part of the brain called the substantia nigra. There is no cure for Parkinson's, but medications and therapies can help manage symptoms.

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mutations

Changes in the DNA sequence.

Mutations are alterations in the genetic code (DNA). They can be caused by errors during DNA replication, exposure to radiation or chemicals, or inherited from parents. Mutations can have various effects, ranging from harmless to causing diseases like cancer.

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psychatric disorders

Mental illnesses that affect mood, thinking, and behavior.

Psychiatric disorders are a broad category of mental health conditions that can significantly impact an individual's thoughts, feelings, and actions. Examples include depression, anxiety disorders, bipolar disorder, schizophrenia, and obsessive-compulsive disorder.