RESEARCH: PARKINSONS
FOLDING PROJECT #17709 PROFILE

The project relates to computer simulations of the serotonin transporter protein, which controls serotonin levels in the brain. Serotonin affects mood, sleep, and appetite, and imbalances are linked to depression and Parkinson's disease. Understanding how mutations in this protein work can help develop new treatments for these disorders.

Note: This TLDR is a simplication and may not be 100% accurate.

The 17000-17710 project series contains simulations of the serotonin transporter, the protein responsible for terminating neurotransmission in neurons.

The neurotransmitter serotonin regulates various functions in the body such as mood, behavior, appettite, and sleep, and is a major drug targets for antidepressants.

Malfunctions in the serotonin transporter have been assoicated with mental disorders including depression and Parkinson's.

Our goal in performing these simulations is to understand how mutations affect the structure and dynamics of the serotonin transporter and provide insights to treat psychatric disorders assoicated with these mutations.

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serotonin transporter

Protein responsible for terminating neurotransmission of serotonin.

The serotonin transporter is a protein found in neurons that helps regulate mood and other functions. It moves serotonin from the synapse (the gap between neurons) back into the neuron, effectively stopping its action. This process is essential for controlling serotonin levels in the brain.

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neurotransmitter

Chemical messenger that transmits signals between neurons.

Neurotransmitters are chemical messengers that allow communication between nerve cells. They are released by one neuron and bind to receptors on another neuron, triggering a response. Neurotransmitters play crucial roles in various bodily functions, including mood, sleep, movement, and memory.

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serotonin

A neurotransmitter that regulates mood, sleep, and other functions.

Serotonin is a neurotransmitter that plays a vital role in regulating mood, sleep, appetite, and digestion. Low levels of serotonin are associated with depression, anxiety, and other mental health disorders. Antidepressant medications often work by increasing serotonin levels in the brain.

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antidepressants

Medications used to treat depression and other mood disorders.

Antidepressants are a class of medications prescribed to treat various mental health conditions, primarily depression. They work by affecting neurotransmitters in the brain, such as serotonin and norepinephrine, which play a role in regulating mood.

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Parkinson's

A neurodegenerative disorder characterized by tremors, stiffness, and slow movements.

Parkinson's disease is a progressive neurological disorder that affects movement. It occurs when nerve cells in the brain that produce dopamine die. This leads to symptoms such as tremors, stiffness, slowness of movement (bradykinesia), and difficulty with balance and coordination.

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mutations

Permanent changes in the DNA sequence.

Mutations are alterations in the genetic code (DNA). They can arise spontaneously or be induced by environmental factors. Mutations can have various effects, ranging from no noticeable change to significant alterations in gene function.

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psychatric disorders

Mental health conditions that affect mood, thinking, and behavior.

Psychiatric disorders encompass a wide range of mental health conditions, including depression, anxiety, bipolar disorder, schizophrenia, and personality disorders. These conditions can significantly impact an individual's thoughts, feelings, behaviors, and overall well-being.