RESEARCH: PARKINSONS
FOLDING PROJECT #17710 PROFILE

The project relates to computer simulations of the serotonin transporter protein, which controls serotonin in our brains. Serotonin affects mood, sleep, and appetite. Simulations help us understand how changes in this protein can cause mental health problems like depression and Parkinson's disease. This knowledge could lead to better treatments.

Note: This TLDR is a simplication and may not be 100% accurate.

The 17000-17710 project series contains simulations of the serotonin transporter, the protein responsible for terminating neurotransmission in neurons.

The neurotransmitter serotonin regulates various functions in the body such as mood, behavior, appettite, and sleep, and is a major drug targets for antidepressants.

Malfunctions in the serotonin transporter have been assoicated with mental disorders including depression and Parkinson's.

Our goal in performing these simulations is to understand how mutations affect the structure and dynamics of the serotonin transporter and provide insights to treat psychatric disorders assoicated with these mutations.

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serotonin transporter

A protein that reabsorbs serotonin from the synapse.

The serotonin transporter is a crucial protein in the brain that helps regulate mood and other functions. It removes serotonin from the space between nerve cells (the synapse), allowing for communication to stop. Disruptions in this transporter can contribute to mental health disorders like depression.

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neurotransmission

The process of transmitting signals across a synapse.

Neurotransmission is how our brain cells (neurons) communicate. It involves the release of chemicals called neurotransmitters that carry messages across tiny gaps between neurons. This process is essential for all brain functions, including thinking, feeling, and moving.

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neurotransmitter

A chemical messenger that transmits signals between neurons.

Neurotransmitters are the brain's chemical messengers. They allow nerve cells to communicate with each other and carry messages throughout the body. Different neurotransmitters have different effects, influencing mood, sleep, concentration, and many other functions.

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antidepressants

Medications used to treat depression and other mood disorders.

Antidepressants are a class of drugs that help improve mood and reduce symptoms of depression. They work by affecting the levels of certain neurotransmitters in the brain, such as serotonin and dopamine.

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Parkinson's

A neurodegenerative disease that affects movement.

Parkinson's disease is a progressive brain disorder that causes tremors, stiffness, slow movements, and difficulty with balance. It occurs when nerve cells in the brain that control movement gradually die.

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mutations

Changes in the DNA sequence.

Mutations are alterations in the genetic code (DNA). They can be caused by various factors and can range from small changes to large-scale deletions or insertions. Mutations can have a wide range of effects on an organism, including no effect, beneficial effects, or harmful effects.

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psychatric disorders

Mental health conditions that affect mood, thinking, and behavior.

Psychiatric disorders encompass a wide range of mental health conditions, including depression, anxiety disorders, bipolar disorder, schizophrenia, and others. They can significantly impact an individual's thoughts, feelings, behaviors, and overall well-being.