RESEARCH: PARKINSONS
FOLDING PROJECT #17793 PROFILE

This project uses computer simulations to study the serotonin transporter, a protein that helps regulate mood, sleep, and other functions. By looking at how changes in the transporter's shape affect its work, scientists hope to better understand mental illnesses like depression and Parkinson's disease and develop new treatments.

Note: This TLDR is a simplication and may not be 100% accurate.

These projects contains simulations of the serotonin transporter, the protein responsible for terminating neurotransmission in neurons.

The neurotransmitter serotonin regulates various functions in the body such as mood, behavior, appettite, and sleep, and is a major drug targets for antidepressants.

Malfunctions in the serotonin transporter have been assoicated with mental disorders including depression and Parkinson's.

Our goal in performing these simulations is to understand how mutations affect the structure and dynamics of the serotonin transporter and provide insights to treat psychatric disorders assoicated with these mutations.

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serotonin transporter

A protein that removes serotonin from synapses.

The serotonin transporter is a protein found in the brain that moves serotonin out of the spaces between neurons (synapses). This process helps regulate serotonin levels and neurotransmission. Disruptions to this transporter can contribute to mental health conditions like depression.

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neurotransmitter

A chemical messenger that transmits signals between neurons.

Neurotransmitters are chemical messengers that allow nerve cells (neurons) to communicate with each other. They carry signals across the tiny gaps (synapses) between neurons, enabling various brain functions like movement, thought, and emotion.

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serotonin

A neurotransmitter that regulates mood, sleep, and appetite.

Serotonin is a chemical messenger in the brain that plays a crucial role in regulating mood, sleep cycles, appetite, and other bodily functions. Imbalances in serotonin levels can contribute to conditions like depression, anxiety, and sleep disorders.

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antidepressants

Medications used to treat depression.

Antidepressants are a class of medications prescribed to help manage symptoms of depression. They work by altering the levels of certain neurotransmitters in the brain, such as serotonin and norepinephrine.

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Parkinson's

A neurodegenerative disorder characterized by tremors, rigidity, and slow movement.

Parkinson's disease is a progressive brain disorder that affects movement. Symptoms include tremors, stiffness, slowness of movement, and difficulty with balance. It's caused by the loss of dopamine-producing cells in the brain.

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mutations

Changes in the DNA sequence.

Mutations are alterations in the genetic code (DNA). They can be spontaneous or caused by environmental factors. Some mutations have no effect, while others can lead to changes in protein structure and function, potentially causing diseases.