RESEARCH: PARKINSONS
FOLDING PROJECT #17702 PROFILE

This project simulates how the serotonin transporter protein works. Serotonin affects mood, sleep, and eating, and problems with this protein can cause depression and Parkinson's disease. The goal is to understand how changes in the protein affect its function and find new ways to treat these diseases.

The 17000-17710 project series contains simulations of the serotonin transporter, the protein responsible for terminating neurotransmission in neurons.

The neurotransmitter serotonin regulates various functions in the body such as mood, behavior, appettite, and sleep, and is a major drug targets for antidepressants.

Malfunctions in the serotonin transporter have been assoicated with mental disorders including depression and Parkinson's.

Our goal in performing these simulations is to understand how mutations affect the structure and dynamics of the serotonin transporter and provide insights to treat psychatric disorders assoicated with these mutations.

serotonin transporter

A protein that regulates serotonin levels in the brain.

The serotonin transporter is a crucial protein found in neurons. It moves serotonin, a neurotransmitter that affects mood, sleep, and other functions, back into the neuron after it has been released. This process helps regulate serotonin levels in the brain.

neurotransmitter

A chemical messenger that transmits signals between neurons.

Neurotransmitters are chemical messengers that allow communication between nerve cells (neurons). They carry signals across the tiny gap between neurons, known as a synapse. This process is essential for all brain functions, including thought, movement, and emotion.

antidepressants

Medications used to treat depression and other mood disorders.

Antidepressants are a class of medications that work by altering the levels or activity of neurotransmitters in the brain. They are commonly prescribed to treat depression, anxiety, and other mental health conditions. Different types of antidepressants work in various ways, but they all aim to improve mood and reduce symptoms.

Parkinson's

A neurodegenerative disorder that affects movement.

Parkinson's disease is a progressive brain disorder that causes tremors, stiffness, slow movements, and balance problems. It occurs when nerve cells in the brain die, leading to a decrease in dopamine production. There is no cure for Parkinson's, but medications and therapies can help manage symptoms.

mutations

Changes in the DNA sequence.

Mutations are alterations in the genetic code (DNA). They can arise spontaneously or be induced by environmental factors. Some mutations are harmless, while others can cause disease or change an organism's traits.

psychatric disorders

Mental illnesses that affect mood, thinking, and behavior.

Psychiatric disorders encompass a wide range of mental health conditions, including depression, anxiety, bipolar disorder, schizophrenia, and others. These disorders can significantly impact an individual's thoughts, emotions, behaviors, and overall well-being.