RESEARCH: PARKINSONS
FOLDING PROJECT #17701 PROFILE

This project simulates how the serotonin transporter protein works and how changes in its structure can cause mental health problems like depression. Understanding these changes could help develop better treatments for these conditions.

Note: This TLDR is a simplication and may not be 100% accurate.

The 17000-17710 project series contains simulations of the serotonin transporter, the protein responsible for terminating neurotransmission in neurons.

The neurotransmitter serotonin regulates various functions in the body such as mood, behavior, appettite, and sleep, and is a major drug targets for antidepressants.

Malfunctions in the serotonin transporter have been assoicated with mental disorders including depression and Parkinson's.

Our goal in performing these simulations is to understand how mutations affect the structure and dynamics of the serotonin transporter and provide insights to treat psychatric disorders assoicated with these mutations.

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serotonin transporter

A protein that moves serotonin across the neuron membrane.

The serotonin transporter is a vital protein found in neurons. It regulates the levels of serotonin, a neurotransmitter that influences mood, sleep, appetite, and behavior. By reabsorbing serotonin from the synapse (the space between neurons), it stops the signal transmission.

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neurotransmission

The process of transmitting signals across a synapse.

Neurotransmission is the complex process by which neurons communicate with each other. It involves the release of chemical messengers called neurotransmitters from one neuron (the presynaptic neuron) across a gap called the synapse to another neuron (the postsynaptic neuron). This transmission of signals allows for information processing and communication throughout the nervous system.

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serotonin

A neurotransmitter that regulates mood, sleep, and appetite.

Serotonin is a chemical messenger in the brain that plays a crucial role in regulating mood, sleep patterns, appetite, and various other cognitive functions. It is often referred to as the 'happy hormone' due to its association with feelings of well-being and happiness.

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antidepressants

Medications that treat depression.

Antidepressants are a class of medications used to treat major depressive disorder and other mood disorders. They work by influencing the levels of neurotransmitters like serotonin and norepinephrine in the brain. Different types of antidepressants have varying mechanisms of action and may be prescribed based on individual patient needs.

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mutations

Changes in the DNA sequence.

Mutations are alterations in the DNA sequence that can occur spontaneously or be induced by environmental factors. These changes can range from single nucleotide substitutions to large-scale chromosomal rearrangements. Mutations can have various effects on gene function and contribute to genetic disorders.

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Parkinson's

A progressive neurodegenerative disorder.

Parkinson's disease is a chronic and progressive neurological condition characterized by the loss of dopamine-producing neurons in the brain. This leads to a variety of motor symptoms, including tremors, stiffness, slowness of movement (bradykinesia), and postural instability.

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psychatric disorders

Mental health conditions that affect mood, thinking, and behavior.

Psychiatric disorders encompass a wide range of mental health conditions that affect an individual's thoughts, feelings, behaviors, and overall well-being. These disorders can include depression, anxiety disorders, bipolar disorder, schizophrenia, and others.

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depression

A mood disorder characterized by persistent sadness and loss of interest.

Depression is a common mental health disorder characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities that were once enjoyable. Symptoms can include changes in appetite, sleep patterns, energy levels, concentration, and self-esteem.