RESEARCH: MYOSINS
FOLDING PROJECT #17427 PROFILE

This project studies myosins, the proteins that power our bodies' movements. Scientists want to understand how drugs could fix problems with myosin that cause heart diseases like cardiomyopathy and heart failure.

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

myosin

Protein responsible for force generation in cells and muscles.

Myosins are a family of proteins crucial for movement within our bodies. They power muscle contractions, allowing us to walk, talk, and perform other actions. Myosins also transport materials inside cells, essential for various biological processes. Defects in myosin can lead to diseases affecting heart function (cardiomyopathies) and overall cellular activity.

proteins

Large biomolecules essential for various cellular functions.

Proteins are the workhorses of our bodies. They perform a wide range of tasks, from building and repairing tissues to catalyzing chemical reactions. Their diverse structures and functions are fundamental to life.

muscle

Tissue responsible for movement and force generation.

Muscles are tissues composed of cells that can contract, generating the force needed for movement. There are three main types of muscle: skeletal (for voluntary movement), smooth (found in internal organs), and cardiac (specific to the heart).

cardiomyopathy

Disease affecting the heart muscle.

Cardiomyopathy refers to a group of diseases that weaken the heart muscle, making it difficult for the heart to pump blood effectively. This can lead to fatigue, shortness of breath, and other symptoms. There are various types of cardiomyopathy, each with different causes and characteristics.

heart failure

Condition where the heart cannot pump enough blood to meet the body's needs.

Heart failure occurs when the heart muscle weakens and can't effectively pump blood throughout the body. This leads to symptoms like fatigue, shortness of breath, and swelling in the legs and ankles. Heart failure is a serious condition that requires medical treatment.