RESEARCH: MYOSINS
FOLDING PROJECT #17413 PROFILE

This project studies myosins, proteins that power movement in our bodies. Understanding how these proteins work could help develop drugs for heart conditions like cardiomyopathies and heart failure.

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

myosins

Proteins responsible for force generation in the body.

Myosins are a family of motor proteins crucial for various cellular functions. They convert chemical energy into mechanical work, enabling muscle contraction, intracellular transport, and cell division. Defects in myosin function can lead to several diseases, including cardiomyopathies and heart failure.

cardiomyopathies

Diseases of the heart muscle.

Cardiomyopathies are a group of conditions that affect the heart muscle's ability to pump blood effectively. They can be caused by various factors, including genetics, infections, and lifestyle choices. Symptoms may include shortness of breath, fatigue, and chest pain.

heart failure

A condition where the heart cannot pump blood effectively.

Heart failure occurs when the heart muscle weakens and cannot pump enough blood to meet the body's needs. It can be caused by various factors, including coronary artery disease, high blood pressure, and cardiomyopathies. Symptoms include shortness of breath, fatigue, and swelling in the legs and feet.

PDB

Protein Data Bank.

The Protein Data Bank (PDB) is a global repository of 3D structural data for large biological molecules like proteins and nucleic acids. This information is crucial for understanding how these molecules function and developing new drugs.

Molecule of the Month

A monthly feature highlighting a significant protein structure in the PDB.

The 'Molecule of the Month' program by the Protein Data Bank (PDB) aims to increase public awareness and understanding of structural biology by showcasing interesting and important protein structures each month.