RESEARCH: MYOSINS
FOLDING PROJECT #17422 PROFILE

This project studies myosins, proteins that power body movements. Researchers want to understand how drugs can fix problems with myosin that cause heart diseases like cardiomyopathies and heart failure.

This project simulates several myosins found in the human body.

Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell.

We are interested in understanding the mechanistic basis of drugs that might be used to treat defects in myosin, including hypertrophic and dilated cardiomyopathies as well as heart failure.

Myosin was featured as the PDB Molecule of the Month in June 2001.

myosin

A motor protein that converts chemical energy into mechanical work

Myosins are a type of protein found in cells that move along filaments, using energy from ATP. They are crucial for muscle contraction, cell division, and intracellular transport. Defects in myosin can lead to various diseases, including heart conditions.

proteins

Large biomolecules composed of amino acids

Proteins are essential building blocks of all living organisms. They perform a wide range of functions, including catalyzing reactions, transporting molecules, providing structural support, and regulating cellular processes.

cardiomyopathies

Diseases of the heart muscle

Cardiomyopathies are a group of disorders that affect the heart muscle, making it harder for the heart to pump blood effectively. Symptoms can include shortness of breath, fatigue, and swelling in the legs and ankles.

heart failure

A condition in which the heart cannot pump blood effectively

Heart failure occurs when the heart muscle weakens or becomes stiff, making it difficult for the heart to pump enough blood to meet the body's needs. This can lead to fatigue, shortness of breath, and fluid retention.

PDB

Protein Data Bank

The Protein Data Bank (PDB) is a global repository of 3D structural data for biological macromolecules. It provides researchers with valuable information about the structure and function of proteins, nucleic acids, and other biomolecules.