RESEARCH: CANCER
FOLDING PROJECT #12705 PROFILE

Class F GPCR proteins help our bodies send signals but sometimes mess up. When they malfunction, it can lead to serious illnesses like cancer. Studying these proteins helps scientists create new drugs to treat these diseases.

Note: This TLDR is a simplication and may not be 100% accurate.

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula, colon cancer and triple negative breast cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

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Class F GPCRs

Family of G protein-coupled receptors.

Class F GPCRs are a type of cell surface receptor that plays a role in various biological processes. They are activated by specific ligands and trigger intracellular signaling cascades. Dysregulation of Class F GPCR signaling has been implicated in several diseases, including cancer and eye disorders.

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Gastric Cancer

Cancer that originates in the stomach.

Gastric cancer is a malignant tumor that develops in the lining of the stomach. It can be caused by various factors, including infection with Helicobacter pylori bacteria, smoking, and diet high in salt and processed foods. Symptoms may include abdominal pain, nausea, vomiting, and weight loss.

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Coloboma

A gap or hole in a part of the eye.

Coloboma is a birth defect that causes a gap or opening in one or more parts of the eye, such as the retina, optic nerve, or iris. It can lead to vision problems and may require surgery to repair.

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Colon Cancer

Cancer that starts in the large intestine (colon).

Colon cancer is a malignant tumor that develops in the lining of the colon. It can be caused by various factors, including diet high in red meat and processed foods, obesity, and family history of the disease. Symptoms may include abdominal pain, changes in bowel habits, and blood in the stool.

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Triple Negative Breast Cancer

A type of breast cancer that does not express estrogen receptors, progesterone receptors, or HER2.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that lacks the expression of certain hormone receptors and HER2 proteins. This makes it more difficult to treat with traditional therapies targeting these receptors.

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Simulation

The process of creating a model or representation of something.

Simulation involves creating a virtual environment or system that mimics real-world processes. This allows researchers to study complex phenomena and test hypotheses in a controlled setting.

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Drug

A substance used for the treatment, prevention, or diagnosis of a disease.

Drugs are chemical compounds that interact with biological systems to produce specific effects. They are designed to treat or prevent diseases, alleviate symptoms, or diagnose medical conditions.