RESEARCH: CANCER
FOLDING PROJECT #12700 PROFILE

This project relates to Class F G Protein Coupled Receptors, which are involved in diseases like gastric and colon cancer. Simulating these receptors helps us understand how they work so we can develop targeted drugs for these cancers.

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula and colon cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Class F GPCRs

G protein-coupled receptors belonging to class F.

Class F G Protein-Coupled Receptors (GPCRs) are a family of cell surface receptors involved in transmitting signals within cells. They play crucial roles in various physiological processes, including sensory perception, hormone regulation, and immune responses. Dysregulation of Class F GPCR signaling has been implicated in several diseases, such as gastric cancer, coloboma of the macula (a retinal birth defect), and colon cancer.

Gastric Cancer

Cancer that originates in the stomach.

Gastric cancer is a malignant tumor that develops in the cells lining the stomach. It is a common type of cancer worldwide, with risk factors including Helicobacter pylori infection, diet high in salt and processed foods, and smoking. Symptoms may include abdominal pain, nausea, vomiting, weight loss, and anemia.

Coloboma of Macula

A birth defect in which a part of the macula (central area of the retina) is missing.

Coloboma of the macula is a rare eye disorder present at birth. It involves a gap or hole in the macula, the central part of the retina responsible for sharp vision. Symptoms include blurred vision, difficulty seeing fine details, and distorted vision. Treatment options may include eyeglasses, contact lenses, or surgery.

Colon Cancer

Cancer that originates in the colon or rectum.

Colon cancer is a malignant tumor that develops in the cells lining the colon or rectum. It is one of the most common cancers worldwide, with risk factors including diet low in fruits and vegetables, obesity, smoking, and family history. Symptoms may include changes in bowel habits, rectal bleeding, abdominal pain, and unexplained weight loss.