RESEARCH: CANCER
FOLDING PROJECT #12703 PROFILE

Class F GPCR proteins are important for our bodies to work properly. Problems with these proteins can cause serious diseases like cancer. The project relates to making computer models of these proteins so scientists can understand how they work and design new drugs to treat these diseases.

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula, colon cancer and triple negative breast cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Class F G Protein Coupled Receptors

A family of cell surface receptors that bind to G proteins and mediate various cellular responses.

Class F GPCRs are a type of receptor found on the surface of cells. They play a crucial role in transmitting signals within the body by activating G proteins. These signals influence a wide range of cellular processes, including growth, differentiation, and metabolism. Disruptions in Class F GPCR signaling have been linked to several diseases, such as cancer and vision disorders.

Gastric Cancer

Cancer that originates in the stomach lining.

Gastric cancer is a malignant growth of cells in the stomach. It can develop due to various factors, including infection with Helicobacter pylori bacteria, genetics, and dietary habits. Symptoms may include abdominal pain, nausea, vomiting, and weight loss. Treatment options vary depending on the stage and severity of the cancer and may include surgery, chemotherapy, and radiation therapy.

Coloboma

A developmental defect that involves a gap or hole in a part of the body.

Coloboma is a rare birth defect characterized by a missing or incompletely formed structure. It can affect various parts of the body, most commonly the eye (coloboma of the macula). In the eye, coloboma often involves the retina and choroid, leading to vision problems. Treatment options may include surgery or corrective lenses.

Colon Cancer

Cancer that originates in the colon (large intestine).

Colon cancer is a type of cancer that starts in the cells lining the colon. Risk factors include a diet high in processed meats and red meat, obesity, and family history of colon cancer. Symptoms may include changes in bowel habits, blood in the stool, abdominal pain, and weight loss. Colonoscopy and other imaging tests are used for diagnosis and treatment options include surgery, chemotherapy, and radiation therapy.

Triple Negative Breast Cancer

A type of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).

Triple-negative breast cancer is a particularly aggressive form of breast cancer that does not respond to hormone therapy or HER2-targeted therapies. It is characterized by the absence of three key receptors: estrogen receptor, progesterone receptor, and HER2. Treatment often involves chemotherapy, radiation therapy, and surgery.