RESEARCH: CANCER
FOLDING PROJECT #12704 PROFILE

This project relates to understanding how a type of protein called Class F GPCRs works. These proteins are involved in diseases like stomach and colon cancer, as well as eye problems. Scientists can use computer simulations to learn more about these proteins and develop new drugs to treat these diseases.

Note: This TLDR is a simplication and may not be 100% accurate.

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula, colon cancer and triple negative breast cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

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Class F G Protein Coupled Receptors

A family of cell surface receptors involved in signal transduction.

Class F G Protein Coupled Receptors (GPCRs) are a type of protein found on the surface of cells. They act as receptors, receiving signals from outside the cell and triggering a response inside. These receptors play a crucial role in many cellular processes, including communication between cells, growth and development, and immune responses. Dysfunction in Class F GPCR signaling has been linked to various diseases such as cancer, developmental disorders, and neurodegenerative diseases.

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Gastric Cancer

Cancer that originates in the stomach lining.

Gastric cancer is a malignant tumor that develops in the cells of the stomach. It's characterized by uncontrolled growth and spread of these abnormal cells. Risk factors include Helicobacter pylori infection, diet high in salt and processed meats, smoking, and family history. Symptoms may include persistent indigestion, unexplained weight loss, nausea, vomiting, and abdominal pain.

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Coloboma

A developmental defect where a part of the eye is missing.

Coloboma is a birth defect that occurs when a part of the developing eye fails to close completely. This can result in a gap or hole in the iris, retina, choroid, or optic nerve. Coloboma can cause vision problems ranging from mild to severe, and may require surgery or other treatments.

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Colon Cancer

Cancer that originates in the colon or rectum.

Colon cancer is a malignant tumor that forms in the tissues of the colon or rectum. Risk factors include age, diet high in red meat and processed foods, lack of physical activity, smoking, and family history. Symptoms may include changes in bowel habits, abdominal pain, rectal bleeding, and weight loss.

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Triple Negative Breast Cancer

TNBC - A type of breast cancer that lacks estrogen receptors, progesterone receptors, and HER2.

Triple-negative breast cancer (TNBC) is a particularly aggressive subtype of breast cancer. It's characterized by the absence of three key proteins: estrogen receptors, progesterone receptors, and HER2. This makes TNBC harder to treat with hormone therapies or targeted therapies that target these specific proteins.

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Drugs

Chemical substances used to treat or prevent disease.

Drugs are chemical compounds designed to have a specific effect on the body. They can be used to treat various conditions, from infections and inflammation to chronic diseases and mental health disorders. The development of new drugs is a complex process that involves extensive research, testing, and regulatory approval.