RESEARCH: CANCER
FOLDING PROJECT #12701 PROFILE

Class F GPCRs are proteins involved in cell signaling. Problems with these proteins can lead to diseases like stomach and colon cancer, as well as eye problems. Studying these proteins through simulations helps us understand how they work and design new drugs to treat these diseases.

Class F G Protein Coupled Receptors Improper signaling through Class F GPCRs is linked to Gastric Cancer, Coloboma of Macula and colon cancer.

Simulation of these proteins helps us to understand their function and therefore be able to design drugs specific to these diseases.

Class F GPCRs

G Protein Coupled Receptors, Class F

Class F G protein-coupled receptors (GPCRs) are a family of membrane proteins involved in cell signaling. They play crucial roles in various physiological processes, including sensory perception, hormone regulation, and immune responses. Dysregulation of Class F GPCR signaling is implicated in several diseases, such as gastric cancer, coloboma of the macula, and colon cancer.

Gastric Cancer

Malignant tumor in the lining of the stomach

Gastric cancer is a type of cancer that develops in the lining of the stomach. It can progress through different stages, from early-stage tumors to advanced and metastatic disease. Symptoms may include persistent abdominal pain, nausea, vomiting, weight loss, and changes in bowel habits. Treatment options depend on the stage and extent of the cancer and may involve surgery, chemotherapy, radiation therapy, or a combination of these approaches.

Coloboma of Macula

A hole or gap in the macula of the eye

Coloboma of the macula is a rare birth defect that affects the central part of the retina called the macula. It results in a hole or gap in this area, leading to blurred vision and difficulty seeing fine details. Treatment options may include corrective lenses, laser surgery, or retinal implants, depending on the severity of the condition.

Colon Cancer

Malignant tumor in the colon

Colon cancer is a type of cancer that develops in the large intestine (colon). It can grow and spread to other parts of the body if left untreated. Symptoms may include changes in bowel habits, abdominal pain, rectal bleeding, and unexplained weight loss. Treatment options for colon cancer depend on the stage and location of the tumor and may involve surgery, chemotherapy, radiation therapy, or a combination of these approaches.